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NHS Blood and Transplant Gene Therapy Hub

Cell Therapy Facility at the Filton Blood Centre (Bristol)The NHSBT Gene Therapy Hub will be hosted within a new, state of the art, 1,000m2 facility for the production of gene therapies under GMP, funded jointly by NHSBT and the Department of Health and Social Care and under construction at the NHSBT Filton Blood Centre (Bristol).

Due to be operational by the end of 2021, the new Hub will support early phase academic-led gene therapy trials and facilitate the provision of cost-effective viral vectors and plasmid DNA to stimulate the UK’s gene therapy sector.

The Hub, led by Dr Jon Smythe and Dr Paul Lloyd-Evans, will provide viral vector manufacturing, training and support services for academic-led groups seeking Adeno Associated Viral (AAV), Lentiviral (LV) vectors and plasmid DNA at GMP and research-grade qualities. It will also support academic-led teams in the translation of their research to the clinic and work with the other Hubs to develop, optimise and deliver a comprehensive training package to generate a highly skilled workforce, serving both the academic and commercial gene therapy communities. 


  • Director: Dr Jon Smythe
  • Co-Director: Dr Paul Lloyd-Evans
  • Viral Vector Hub Manager: Dr Sujith Sebastian
  • Project Manager: Charlotte McHugh

Hub Locations