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Sheffield


The University of Sheffield Gene Therapy Innovation Manufacturing Centre (GTIMC)

The University of Sheffield Gene Therapy Innovation Manufacturing Centre (GTIMC)Sheffield’s GTIMC, led by Professor Mimoun Azzouz, builds on a strong history of translational gene therapy research at the University of Sheffield and partners. The centre includes a state-of-the-art GMP manufacturing facility, located in the University of Sheffield’s Innovation District, that will support gene therapy projects emerging from UK universities. The facility will provide clinical grade AAV material for human trials at NHS sites within the national network. The GTIMC will deliver translational and regulatory support alongside an extensive training and skills programme to enable upskilling and address shortage of skills in GMP manufacturing and process development.

Professor Mimoun Azzouz
Professor Mimoun Azzouz

People


  • Director: Professor Mimoun Azzouz
  • GTIMC Manager: Kevin Garlick

Sheffield GTIMC Hub Timeline

August 21
August 2022
October 2022
December 2022
January 2023
February 2023
March 2023
July 2026

Project Launch

New building completion

Tech transfer of AAV platform complete

Scale-up to 50L complete

First validation studies commence

Official opening event

First GMP vector manufactured

Transition to self-sustaining Hub

Hub Locations