The University of Sheffield Gene Therapy Innovation and Manufacturing Centre (GTIMC)
Sheffield’s GTIMC, led by Professor Mimoun Azzouz, builds on a strong history of translational gene therapy research at the University of Sheffield and partners. The centre includes a state-of-the-art GMP manufacturing facility, located in the University of Sheffield’s Innovation District, created to support gene therapy projects emerging from UK universities. The facility provides R&D grade and GMP-like AAV material for toxicology studies. From mid 2027 the GTIMC aims to provide clinical grade AAV material for human trials at NHS sites within the national network. The GTIMC delivers translational and regulatory support alongside an extensive training and skills programme to enable upskilling and address shortage of skills in GMP manufacturing and process development.
